Omega Chapter of Alpha Kappa Alpha Sorority, Incorporated was chartered on December 1, 1925 with students from Cleveland, Mather and Oberlin Colleges. Twelve new members were introduced to the public in early 1926.

The Chartering Members of Omega Chapter of Alpha Kappa Alpha Sorority, Incorporated are:
                            Emily Chabous                                 Mary Ramey
                            Anna Cook                                      Winona Douglas Reynolds
                            Florence Budy Fairfax                  Edna Mayer Tyler
                            Nelle Hackney                               Loretta Conners White
                            Catherine McKnight                     Audrey Wright
                            Editha Grant Louise                      Hazel Haynes

Over the years, Omega Chapter has widened its sphere of influence to include college women of superior academic achievement and altruistic intent from nine Cleveland area campuses:
                           Baldwin Wallace University               Cleveland Institute of Music
                           Case Western Reserve University     Cleveland State University
                           John Carroll University                      Cleveland Institute of Art                                          
                              Notre Dame College                             Ursuline College

The Chapter's Community service projects have been ambitious in scope and successful in execution. in addition, Omega Chapter has collaborated with its supervising Graduate Chapter Alpha Omega on numerous occasions, which include  Cluster meetings, community events and Regional Conferences. 

Omega chapter made history yet again in July 2016 when chapter member Keniece Gray was elected as the international Second Vice President of Alpha Kappa Alpha Sorority, Incorporated for the 2016 - 2018 term.